/*********************************************************************************

# Copyright 2017 Observational Health Data Sciences and Informatics

#

#

# Licensed under the Apache License, Version 2.0 (the "License");

# you may not use this file except in compliance with the License.

# You may obtain a copy of the License at

#

#     http://www.apache.org/licenses/LICENSE-2.0

#

# Unless required by applicable law or agreed to in writing, software

# distributed under the License is distributed on an "AS IS" BASIS,

# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.

# See the License for the specific language governing permissions and

# limitations under the License.

********************************************************************************/

/*******************************************************************************



PURPOSE: Generate Era table (based on conversion script from V4  V5).



last revised: Jun 2017

authors:  Patrick Ryan, Chris Knoll, Anthony Sena, Vojtech Huser





OHDSI-SQL File Instructions

-----------------------------



 1. Set parameter name of schema that contains CDMv4 instance

    (@SOURCE_CDMV4, @SOURCE_CDMV4_SCHEMA)

 2. Set parameter name of schema that contains CDMv5 instance

    ([CDM], [CDM].[CDMSCHEMA])

 3. Run this script through SqlRender to produce a script that will work in your

    source dialect. SqlRender can be found here: https://github.com/OHDSI/SqlRender

 4. Run the script produced by SQL Render on your target RDBDMS.



<RDBMS> File Instructions

-------------------------



 1. This script will hold a number of placeholders for your CDM V4 and CDMV5

    database/schema. In order to make this file work in your environment, you

	should plan to do a global "FIND AND REPLACE" on this file to fill in the

	file with values that pertain to your environment. The following are the

	tokens you should use when doing your "FIND AND REPLACE" operation:



	

     [CMD]

	 [CDM].[CDMSCHEMA]

	



*********************************************************************************/

/* SCRIPT PARAMETERS */



	

	 -- The target CDMv5 database name

	 -- the target CDMv5 database plus schema



SET search_path TO [CDM];







/****



DRUG ERA

Note: Eras derived from DRUG_EXPOSURE table, using 30d gap



 ****/

DROP TABLE cteDrugTarget IF EXISTS;



/* / */



-- Normalize DRUG_EXPOSURE_END_DATE to either the existing drug exposure end date, or add days supply, or add 1 day to the start date

CREATE TEMP TABLE cteDrugTarget


AS
SELECT
d.DRUG_EXPOSURE_ID

	,d.PERSON_ID

	,c.CONCEPT_ID

	,d.DRUG_TYPE_CONCEPT_ID

	,DRUG_EXPOSURE_START_DATE

	,COALESCE(DRUG_EXPOSURE_END_DATE, (DRUG_EXPOSURE_START_DATE + DAYS_SUPPLY), (DRUG_EXPOSURE_START_DATE + 1)) AS DRUG_EXPOSURE_END_DATE

	,c.CONCEPT_ID AS INGREDIENT_CONCEPT_ID


FROM
[CDM].[CDMSCHEMA].DRUG_EXPOSURE d

INNER JOIN [CDM].[CDMSCHEMA].CONCEPT_ANCESTOR ca ON ca.DESCENDANT_CONCEPT_ID = d.DRUG_CONCEPT_ID

INNER JOIN [CDM].[CDMSCHEMA].CONCEPT c ON ca.ANCESTOR_CONCEPT_ID = c.CONCEPT_ID

WHERE c.VOCABULARY_ID = 'RxNorm'

	AND c.CONCEPT_CLASS_ID = 'Ingredient';



/* / */



DROP TABLE cteEndDates IF EXISTS;



/* / */



CREATE TEMP TABLE cteEndDates


AS
SELECT
PERSON_ID

	,INGREDIENT_CONCEPT_ID

	,(EVENT_DATE + - 30) AS END_DATE -- unpad the end date


FROM
(

	SELECT E1.PERSON_ID

		,E1.INGREDIENT_CONCEPT_ID

		,E1.EVENT_DATE

		,COALESCE(E1.START_ORDINAL, MAX(E2.START_ORDINAL)) START_ORDINAL

		,E1.OVERALL_ORD

	FROM (

		SELECT PERSON_ID

			,INGREDIENT_CONCEPT_ID

			,EVENT_DATE

			,EVENT_TYPE

			,START_ORDINAL

			,ROW_NUMBER() OVER (

				PARTITION BY PERSON_ID

				,INGREDIENT_CONCEPT_ID ORDER BY EVENT_DATE

					,EVENT_TYPE

				) AS OVERALL_ORD -- this re-numbers the inner UNION so all rows are numbered ordered by the event date

		FROM (

			-- select the start dates, assigning a row number to each

			SELECT PERSON_ID

				,INGREDIENT_CONCEPT_ID

				,DRUG_EXPOSURE_START_DATE AS EVENT_DATE

				,0 AS EVENT_TYPE

				,ROW_NUMBER() OVER (

					PARTITION BY PERSON_ID

					,INGREDIENT_CONCEPT_ID ORDER BY DRUG_EXPOSURE_START_DATE

					) AS START_ORDINAL

			FROM cteDrugTarget



			UNION ALL



			-- add the end dates with NULL as the row number, padding the end dates by 30 to allow a grace period for overlapping ranges.

			SELECT PERSON_ID

				,INGREDIENT_CONCEPT_ID

				,(DRUG_EXPOSURE_END_DATE + 30)

				,1 AS EVENT_TYPE

				,NULL

			FROM cteDrugTarget

			) RAWDATA

		) E1

	INNER JOIN (

		SELECT PERSON_ID

			,INGREDIENT_CONCEPT_ID

			,DRUG_EXPOSURE_START_DATE AS EVENT_DATE

			,ROW_NUMBER() OVER (

				PARTITION BY PERSON_ID

				,INGREDIENT_CONCEPT_ID ORDER BY DRUG_EXPOSURE_START_DATE

				) AS START_ORDINAL

		FROM cteDrugTarget

		) E2 ON E1.PERSON_ID = E2.PERSON_ID

		AND E1.INGREDIENT_CONCEPT_ID = E2.INGREDIENT_CONCEPT_ID

		AND E2.EVENT_DATE <= E1.EVENT_DATE

	GROUP BY E1.PERSON_ID

		,E1.INGREDIENT_CONCEPT_ID

		,E1.EVENT_DATE

		,E1.START_ORDINAL

		,E1.OVERALL_ORD

	) E

WHERE 2 * E.START_ORDINAL - E.OVERALL_ORD = 0;



/* / */



DROP TABLE cteDrugExpEnds IF EXISTS;



/* / */



CREATE TEMP TABLE cteDrugExpEnds


AS
SELECT
d.PERSON_ID

	,d.INGREDIENT_CONCEPT_ID

	,d.DRUG_TYPE_CONCEPT_ID

	,d.DRUG_EXPOSURE_START_DATE

	,MIN(e.END_DATE) AS ERA_END_DATE


FROM
cteDrugTarget d

INNER JOIN cteEndDates e ON d.PERSON_ID = e.PERSON_ID

	AND d.INGREDIENT_CONCEPT_ID = e.INGREDIENT_CONCEPT_ID

	AND e.END_DATE >= d.DRUG_EXPOSURE_START_DATE

GROUP BY d.PERSON_ID

	,d.INGREDIENT_CONCEPT_ID

	,d.DRUG_TYPE_CONCEPT_ID

	,d.DRUG_EXPOSURE_START_DATE;



/* / */



INSERT INTO [CDM].[CDMSCHEMA].drug_era

SELECT row_number() OVER (

		ORDER BY person_id

		) AS drug_era_id

	,person_id

	,INGREDIENT_CONCEPT_ID

	,min(DRUG_EXPOSURE_START_DATE) AS drug_era_start_date

	,ERA_END_DATE

	,COUNT(*) AS DRUG_EXPOSURE_COUNT

	,30 AS gap_days

FROM cteDrugExpEnds

GROUP BY person_id

	,INGREDIENT_CONCEPT_ID

	,drug_type_concept_id

	,ERA_END_DATE;



























































/****



CONDITION ERA

Note: Eras derived from CONDITION_OCCURRENCE table, using 30d gap



 ****/

DROP TABLE condition_era_phase_1 IF EXISTS;



/* / */



DROP TABLE cteConditionTarget IF EXISTS;



/* / */



-- create base eras from the concepts found in condition_occurrence

CREATE TEMP TABLE cteConditionTarget


AS
SELECT
co.PERSON_ID

	,co.condition_concept_id

	,co.CONDITION_START_DATE

	,COALESCE(co.CONDITION_END_DATE, (CONDITION_START_DATE + 1)) AS CONDITION_END_DATE


FROM
[CDM].[CDMSCHEMA].CONDITION_OCCURRENCE co;



/* / */



DROP TABLE cteCondEndDates IF EXISTS;



/* / */



CREATE TEMP TABLE cteCondEndDates


AS
SELECT
PERSON_ID

	,CONDITION_CONCEPT_ID

	,(EVENT_DATE + - 30) AS END_DATE -- unpad the end date


FROM
(

	SELECT E1.PERSON_ID

		,E1.CONDITION_CONCEPT_ID

		,E1.EVENT_DATE

		,COALESCE(E1.START_ORDINAL, MAX(E2.START_ORDINAL)) START_ORDINAL

		,E1.OVERALL_ORD

	FROM (

		SELECT PERSON_ID

			,CONDITION_CONCEPT_ID

			,EVENT_DATE

			,EVENT_TYPE

			,START_ORDINAL

			,ROW_NUMBER() OVER (

				PARTITION BY PERSON_ID

				,CONDITION_CONCEPT_ID ORDER BY EVENT_DATE

					,EVENT_TYPE

				) AS OVERALL_ORD -- this re-numbers the inner UNION so all rows are numbered ordered by the event date

		FROM (

			-- select the start dates, assigning a row number to each

			SELECT PERSON_ID

				,CONDITION_CONCEPT_ID

				,CONDITION_START_DATE AS EVENT_DATE

				,- 1 AS EVENT_TYPE

				,ROW_NUMBER() OVER (

					PARTITION BY PERSON_ID

					,CONDITION_CONCEPT_ID ORDER BY CONDITION_START_DATE

					) AS START_ORDINAL

			FROM cteConditionTarget



			UNION ALL



			-- pad the end dates by 30 to allow a grace period for overlapping ranges.

			SELECT PERSON_ID

				,CONDITION_CONCEPT_ID

				,(CONDITION_END_DATE + 30)

				,1 AS EVENT_TYPE

				,NULL

			FROM cteConditionTarget

			) RAWDATA

		) E1

	INNER JOIN (

		SELECT PERSON_ID

			,CONDITION_CONCEPT_ID

			,CONDITION_START_DATE AS EVENT_DATE

			,ROW_NUMBER() OVER (

				PARTITION BY PERSON_ID

				,CONDITION_CONCEPT_ID ORDER BY CONDITION_START_DATE

				) AS START_ORDINAL

		FROM cteConditionTarget

		) E2 ON E1.PERSON_ID = E2.PERSON_ID

		AND E1.CONDITION_CONCEPT_ID = E2.CONDITION_CONCEPT_ID

		AND E2.EVENT_DATE <= E1.EVENT_DATE

	GROUP BY E1.PERSON_ID

		,E1.CONDITION_CONCEPT_ID

		,E1.EVENT_DATE

		,E1.START_ORDINAL

		,E1.OVERALL_ORD

	) E

WHERE (2 * E.START_ORDINAL) - E.OVERALL_ORD = 0;



/* / */



DROP TABLE cteConditionEnds IF EXISTS;



/* / */



CREATE TEMP TABLE cteConditionEnds


AS
SELECT
c.PERSON_ID

	,c.CONDITION_CONCEPT_ID

	,c.CONDITION_START_DATE

	,MIN(e.END_DATE) AS ERA_END_DATE


FROM
cteConditionTarget c

INNER JOIN cteCondEndDates e ON c.PERSON_ID = e.PERSON_ID

	AND c.CONDITION_CONCEPT_ID = e.CONDITION_CONCEPT_ID

	AND e.END_DATE >= c.CONDITION_START_DATE

GROUP BY c.PERSON_ID

	,c.CONDITION_CONCEPT_ID

	,c.CONDITION_START_DATE;



/* / */



INSERT INTO [CDM].[CDMSCHEMA].condition_era (

	condition_era_id

	,person_id

	,condition_concept_id

	,condition_era_start_date

	,condition_era_end_date

	,condition_occurrence_count

	)

SELECT row_number() OVER (

		ORDER BY person_id

		) AS condition_era_id

	,person_id

	,CONDITION_CONCEPT_ID

	,min(CONDITION_START_DATE) AS CONDITION_ERA_START_DATE

	,ERA_END_DATE AS CONDITION_ERA_END_DATE

	,COUNT(*) AS CONDITION_OCCURRENCE_COUNT

FROM cteConditionEnds

GROUP BY person_id

	,CONDITION_CONCEPT_ID

	,ERA_END_DATE;



