Health Information Privacy Laboratory

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2020


• Data Sharing that Enables Post-Approval Drug and Device Research and Protects Patient Privacy: Best Practice Recommendations
  Ameet Sarpatwari, Bradley Malin, Aaron Kesselheim, Joshua Gagne, and Sebastian Schneeweiss
  A book chapter for Big Data, Health Law, and Bioethics, in press.


• Dynamic Informed Consent: A Potential Solution for Ethical Dilemmas in Population Sequencing Initiatives
  Fida Dankar, Marton Gergely, Bradley Malin, Radja Badji, Samar Dankar, and Khaled Shuaib
  Computational and Structural Biology Journal, 2020; 18: 913-921.
  


• Enabling Realistic Health Data Re-identification Risk Assessment Through Adversarial Modeling
  Weiyi Xia, Yongtai Liu, Zhiyu Wan, Yevgeniy Vorobeychik, Murat Kantarcioglu, Steve Nyemba, Ellen Wright Clayton, and Bradley Malin
  Journal of the American Medical Informatics Association, in press.
  


• Game Theory for Privacy-Preserving Genomic Data
  Zhiyu Wan, Yevgeniy Vorobeychik, Elen Wright Clayton, Murat Kantarcioglu, and Bradley Malin
  In Responsible Genomic Data Sharing, Elsevier Press. 2020, in press.
  
  
• Generating Electronic Health Records with Multiple Data Types and Constraints
  Chao Yan, Ziqi Zhang, Steve Nyemba, and Bradley Malin
  Proceedings of the American Medical Informatics Association Annual Symposium, 2020; in press.
  


• Health and Kinship Matter: Learning about Direct-to-Consumer Genetic Testing User Experiences via Online Discussions
  Zhijun Yin, Lijun Song, Ellen Wright Clayton, and Bradley Malin
  PLoS One, 2020; 15(9): e0238644.
  


• Leveraging Blockchain for Immutable Logging and Querying Across Multiple Sites
  Mustafa Ozdayi, Murat Kantarcioglu, and Bradley Malin
  BMC Medical Genomics, 2020; in press.
  


• Lucene-P2: a distributed platform for privacy-preserving text-based search
  Wei Jiang, Nitish Uplavikar, and Bradley Malin
  IEEE Transactions on Secure and Dependable Computing, 2020.
  


• SCOR: A Secure International Informatics Architecture to Investigate COVID-19
  Jean Louis Raisaro, Francesco Marino, Juan Troncoso-Pastoriza, Raphaelle Beau-Lejdstrom, Riccardo Bellazzi, Elmer V. Bernstam, Mauro Bucalo, Yong Chen, Assaf Gottlieb, Arif Harmanci, Miran Kim, Yejin Kim, Jeffrey Klann, Catherine Klersy, Bradley Malin, Marie Méan, Fabian Prasser, Luigia Scudeller, Ali Torkamani, Julien Vaucher, Mamta Puppala; Stephen T.C. Wong, Milana Frenkel-Morgenstern, Hua Xu, Baba Maiyaki Musa, Abdulrazaq G. Habib, Adam Wilcox, Hamisu M. Salihu, Heidi Sofia, Xiaoqian Jiang, and Jean Pierre Hubaux
  Journal of the American Medical Informatics Association, 2020; 27(11): 1721-1726.
  


• SynTEG: A Framework for Temporal Structured Electonic Health Data Simulation
  Chao Yan, Ziqi Zhang, Thomas Lasko, Jimeng Sun, and Bradley Malin
  Journal of the American Medical Informatics Association, in press.
  


• To Warn or Not to Warn: Online Signaling in Audit Games
  Chao Yan, Haifeng Xu, Yevgeniy Vorobeychik, Bo Li, Daniel Fabbri, and Bradley Malin
  Proceedings of the 36th IEEE International Conference on Data Engineering (ICDE), 2020.
  A version of this was also presented at the 2020 AI for Social Good Workshop.



2019

• The "All of Us" Research Program
  The All of Us Research Program Investigators
  New England Journal of Medicine, 2019; 381: 668-676.
  


• Biomedical Research Cohort Membership Disclosure on Social Media
  Yongtai Liu, Chao Yan, Zhijun Yin, Zhiyu Wan, Weiyi Xia, Murat Kantarcioglu, Yevgeniy Vorobeychik, Ellen Wright Clayton, and Bradley Malin
  Proceedings of the American Medical Informatics Association Annual Symposium, 2019; forthcoming.
  


• Determining the Impact of Missing Values on Blocking in Record Linkage
  Imrul Chowdhury Anindya, Murat Kantarcioglu, and Bradley Malin
  Proceedings of the Pacific-Asia Conference on Knowledge Discovery and Data Mining, 2019: 262-274.
  


• Database Audit Workload Prioritization via Game Theory
  Chao Yan, Bo Li, Yevgeniy Vorobeychik, Aron Laszka, Daniel Fabbri, and Bradley Malin
  ACM Transactions on Privacy and Security, 2019; 22(3): 17.
  


• DMMS: A Decentralized Blockchain Ledger for the Management of Medication Histories
  Patrick Li, Scott Nelson, Bradley Malin, and You Chen
  Blockchain in Healthcare Today, 2019; 2: 38.
  


• Efficient Active Learning for Electronic Medical Record De-identification
  Muqun Li, Martin Scaiano, Khaled El Emam, and Bradley Malin
  Proceedings of the AMIA Informatics Summit, 2019: 462-471.
  


• Ensuring Electronic Medical Record Simulation Through Better Training, Modeling, and Evaluation
  Ziqi Zhang, Chao Yan, Diego Mesa, Jimeng Sun, and Bradley Malin
  Journal of the American Medical Informatics Association, 2019; 26(12): 1536-1544.
  


• Ensuring Electronic Medical Record Simulation Through Better Training, Modeling, and Evaluation
  David Carrell, David Cronkite, Muqun Li, Steve Nyemba, Bradley Malin, John Aberdeen, and Lynette Hirschman
  Journal of the American Medical Informatics Association, 2019; forthcoming.
  


• Public Attitudes Toward Direct to Consumer Genetic Testing
  Grayson Ruhl, James Hazel, Ellen Wright Clayton, and Bradley Malin
  Proceedings of the American Medical Informatics Association Annual Symposium, 2019; forthcoming.
  


• Systematizing Genome Privacy Research: A Privacy-Enhancing Technologies Perspective
  Alexandros Mittos, Bradley Malin, and Emiliano de Cristofaro
  Proceedings of the Privacy Enhancing Technologies Symposium, 2019: 87-107.
  


2018


• Automated Collection of Pathogen-Specific Diagnostic Data for Real-time Syndromic Epidemiological Studies
  Lindsay Meyers, Christine C. Ginocchio, Aimie N. Faucett, Frederick S. Nolte, Per H. Gesteland, Amy Leber, Diane Janowiak, Virginia Donovan, Jennifer Dien Bard, Silvia Spitzer, Kathleen A. Stellrecht, Hossein Salimnia, Rangaraj Selvarangan, Stefan Juretschko, Judy A. Daly, Jeremy C. Wallentine, Kristy Lindsey, Franklin Moore, Sharon L. Reed, Maria Aguero-Rosenfeld, Paul D. Fey, Gregory A. Storch, Steve J. Melnick, Christine C. Robinson, Jennifer F. Meredith, Camille V. Cook, Robert K. Nelson, Jay D. Jones, Samuel V. Scarpino, Benjamin M. Althouse, Kirk M. Ririe, Bradley Malin, Mark A. Poritz
  JMIR Public Health and Surveillance, 2018; 4(3): e59.
  


• A Crowdsourcing Framework for Sensitive and Complex Data Sets
  Cheng Ye, Joseph Coco, Bradley Malin, Thomas Lasko, Laurie Novak, Joshua Denny, Yevgeniy Vorobeychik, Chen Hajaj, Anna Epishova, Henry Bogardus, and Daniel Fabbri
  Proceedings of the American Medical Informatics Association Informatics Summit, 2018: 273-280.
  


• Detecting the Presence of an Individual in Phenotypic Summary Data
  Yongtai Liu, Zhiyu Wan, Weiyi Xia, Murat Kantarcioglu, Yevgeniy Vorobeychik, Ellen Wright Clayton, Abel Kho, David Carrell, and Bradley Malin
  Proceedings of the American Medical Informatics Association Annual Fall Symposium (AMIA), 2018: forthcoming.
  


• Enabling Open Science Initiatives in Clinical Psychology and Psychiatry Without Sacrificing Patient Privacy: Current Practices and Future Challenges
  Colin Walsh, Weiyi Xia, Muqun Li, Joshua Denny, Paul Harris, and Bradley Malin
  Advances in Methods and Practices in Psychological Science, 2018; 1(1): 104-114.
  


• Get Your Workload in Order: Game Theoretic Prioritization of Database Auditing
  Chao Yan, Bo Li, Daniel Fabbri, Aaron Laszka, Yevgeniy Vorobeychik, and Bradley Malin
  Proceedings of the 34th IEEE International Conference on Data Engineering (ICDE), 2018: 1304-1307.
  


• Is it time to establish a universal forensic database?
  James Hazel, Ellen Wright Clayton, Bradley Malin, and Chris Slobogin.
  Science, 2018: 362(6417): 898-900.
  


• It's All in the Timing: Calibrating Temporal Penalties for Biomedical Data Sharing
  Weiyi Xia, Zhiyu Wan, Zhijun Yin, James Gaupp, Yongtai Liu, Ellen Wright Clayton, Murat Kantarcioglu, Yevgeniy Vorobeychik, and Bradley Malin
  Journal of the American Medical Informatics Association, 2018; 25(1): 25-31.
  


• Mining the Best Observational Window to Model Social Phenomena
  Chao Yan, Zhijun Yin, Stanley Xiang, You Chen, Yevgeniy Vorobeychik, Daniel Fabbri, Abel Kho, David Liebovitz, and Bradley Malin
  Proceedings of the 4th IEEE International Conference on Collaboration and Internet Computing (CIC), 2018: 46-55.
  


• Registered Access: Authorizing Data Access
  Stephanie Dyke, Mikael Linden, Ilkka Lappalainen, Jordi Rambla De Argila, William Knox Carey, David Lloyd, J. Dylan Spalding, Moran Cabili, Giselle Kerry, Julia Foreman, Timothy Cutts, Mahsa Shabani, Laura Rodriguez, Maximilian Haeussler, Brian Walsh, Xiaoqian Jiang, Shuang Wang, Daniel Perrett, Tiffany Boughtwood, Andreas Matern, Anthony Brookes, Miro Cupak, Marc Fiume, Ravi Pandya, Ilia Tulchinsky, Serena Scollen, Samir Das, Alan Evans, Bradley Malin, Stephan Beck, Steven Brenner, Tommi Nyronen, Niklas Blomberg, Helen Firth, Matthew Hurles, Anthony Philippakis, Gunnar Ratsch, Michael Brudno, Kym Boycott, Heidi Rehm, Michael Baudis, Kazuto Kato, Bartha Knoppers, Dixie Baker, and Paul Flicek
  European Journal of Human Genetics, 2018; 26(12): 1721-1731.
  


• A Systematic Literature Review of Individuals' Perspectives on Privacy and Genetic Information in the United States
  Ellen Wright Clayton, Colin Halverson, Nila Sathe, and Bradley Malin
  PLoS One, 2018; 13(10): e0204417.
  


2017


• Assessing Privacy Risks in Biospecimen Research
  Ellen Wright Clayton and Bradley Malin
  A book chapter for H.F. Lynch and I.G. Cohen, eds: Specimen Science: Ethics and Policy Implications, MIT Press, 2017.


• Building a Dossier on the Cheap: Integrating Distributed Personal Data Resources Under Cost Constraints
  Imrul Chowdhury Anindya, Harichandan Roy, Murat Kantarcioglu, and Bradley Malin
  Proceedings of the 26th ACM Conference on Information and Knowledge Management (CIKM), 2017; 1549-1558.


• A Community Effort to Protect Genomic Data Sharing, Collaboration and Outsourcing
  Shuang Wang, Xiaoqian Jiang, Haixu Tang, Xiaofeng Wang, Diyue Bu, Knox Carey, Stephanie OM Dyke, Dov Fox, Chao Jiang, Kristin Lauter, Bradley Malin, Heidi Sofia, Amalio Telenti, Lei Wang, Wenhao Wang, and Lucila Ohno-Machado
  Genomic Medicine, 2017; 2: 33.


• Controlling the Signal: Practical Protection of Genomic Data Sharing In Beacon Services
  Zhiyu Wan, Yevgeniy Vorobeychik, Murat Kantarcioglu, and Bradley Malin
  BMC Medical Genomics, 2017; 10(Suppl 2):39.


• Evaluating the Effectiveness of Auditing Rules for Electronic Health Record Systems
  Monica Hedda, Chao Yan, Bradley Malin, and Daniel Fabbri
  Proceedings of the 2017 American Medical Informatics Association Annual Fall Symposium (AMIA), 2017: 866-875.


• Expanding Access to Large-Scale Genomic Data While Promoting Privacy: A Game Theoretic Approach
  Zhiyu Wan, Yevgeniy Vorobeychik, Weiyi Xia, Ellen Wright Clayton, Murat Kantarcioglu, and Bradley Malin
  American Journal of Human Genetics, 2017; 100(2): 316-322.


• A Game Theoretic Approach to Alert Priortization
  Aron Laszka, Yevgenity Vorobeychik, Daniel Fabbri, Chao Yan, and Bradley Malin
  Proceeedings of the AAAI Workshop on Artificial Intelligence for Cyber Security (AICS), 2017.


• Generating Multi-label Discrete Patient Records using Generative Adversarial Networks
  Edward Choi, Siddharth Biswal, Bradley Malin, Jon Duke, Walter F. Stewart, Jimeng Sun
  Proceedings of the Machine Learning in Healthcare Conference (MLHC), 2017: forthcoming.


• Identifying Collaborative Care Teams through Electronic Medical Record Utilization Patterns
  You Chen, Nancy Lorenzi, Warren Sandberg, Kelly Wolgast, and Bradley Malin
  Journal of the American Medical Informatics Association, 2017; 24(e1): e111-e120.


• An Iterative Classification Scheme for Sanitizing Large-Scale Datasets
  Bo Li, Yevgeniy Vorobeychik, Muqun (Rachel) Li, and Bradley Malin
  IEEE Transactions on Data and Knowledge Engineering, 2017; 29(3): 698-711.


• The Need for Better Data Breach Statistics
  Daniel Fabbri, Mark Frisse, and Bradley Malin
  JAMA Internal Medicine, 2017; 177(11): 1696.


• An Open Source Tool for Game Theoretic Health Data De-identification
  Fabian Prasser, James Gaupp, Zhiyu Wan, Weiyi Xia, Yevgeniy Vorobeychik, Murat Kantarcioglu, Klaus Kuhn, and Bradley Malin
  Proceedings of the 2017 American Medical Informatics Association Annual Fall Symposium (AMIA), 2017: 1430-1439.


• Towards a Privacy Preserving Cohort Discovery Framework for Clinical Research Networks
  Jaiwai Yuan, Bradley Malin, Francois Modave, Yi Guo, William Hogan, and Elizabeth Shenkman, Jiang Bian
  Journal of Biomedical Informatics, 2017; 66: 42-51.


2016

• CheapSMC: A Framework to Minimize Secure Multiparty Computation Costs in the Cloud
  Erman Pattuk, Murat Kantarcioglu, Huseyin Ulusoy, Bradley Malin
  Proceedings of the 30th Annual Conference on Data and Applications Security and Privacy (DBSec), 2016: 285-294.


• Is the Juice Worth the Squeeze? Costs and Benefits of Multiple Human Annotators for Clinical Text De-identification
  David Carrell, David Cronkite, Bradley Malin, John Aberdeen, and Lynette Hirschman
  Methods of Information in Medicine, 2016; 55(4): 356-364.


• A Multi-Institution Evaluation of Clinical Profile Anonymization
  Raymond Heatherly, Luke Rasmussen, Peggy Peissig, Jennifer Pacheco, Paul Harris, Joshua Denny, and Bradley Malin
  Journal of the American Medical Informatics Association, 2016; 23(e1): e131-e137.


• #PrayForDad: Learning the Semantics Behind Why Social Media Users Disclose Health Information
  Zhijun Yin, You Chen, Jimeng Sun, Daniel Fabbri and Bradley Malin
  Proceedings of the AAAI Conference on Web and Social Media (ICWSM). 2016; 456-465.


• Optimizing Secure Classification Performance with Privacy-Aware Feature Selection
  Erman Pattuk, Murat Kantarcioglu, Huseyin Ulusoy, Bradley Malin
  Proceedings of the 32nd IEEE International Conference on Data Engineering, 2016; 217-228.


• Optimizing Annotation Resources for Natural Language De-identification via a Game Theoretic Framework
  Muqun Li, David Carrell, John Aberdeen, Lynette Hirschman, Jacqueline Kirby, Bo Li, Yevgeniy Vorobeychik, and Bradley Malin
  Journal of Biomedical Informatics. 2016; 61: 97-109.


• Preserving Temporal Relations in Clinical Data While Maintaining Privacy
  George Hripcsak, Parsa Mirhaji, Alex Low, and Bradley Malin
  Journal of the American Medical Informatics Association, 2016; 23(6): 1040-1045.


• Protecting Genomic Data Analytics in the Cloud: State of the Art and Opportunities
  Haixu Tang, Xiaoqian Jiang, Xiaofeng Wang, Shuang Wang, Heidi Sofia, Dov Fox, Kristin Lauter, Bradley Malin, Amalio Telenti, Li Xiong, Lucila Ohno-Machado
  BMC Medical Genomics. 2016; 9(1): 63.


2015

• Anonymizing and Sharing Patient-Level Data
  Khaled El Emam, Sam Rodgers, and Bradley Malin
  BMJ. 2015; 350: h1139


• Assessing Data Intrusion Threats
  Daniel Barth-Jones, Khaled El Emam, Jane Bambauer, Ann Cavoukian, and Bradley Malin
  Science. 2015; 348(6231): 194-195


• Building Bridges Across Electronic Health Record Systems Through Inferred Phenotypic Topics
  You Chen, Joydeep Ghosh, Cosmin (Adi) Bejan, Carl Gunter, Siddharth Gupta, Abel Kho, David Liebovitz, Jimeng Sun, Joshua Denny, and Bradley Malin
  Journal of Biomedical Informatics, 2015; 55: 82-93


• Design and Implementation of a Privacy Preserving Electronic Health Record Linkage Tool in Chicago
  Abel Kho, John Cashy, Kathryn Jackson, Adam Pah, Satyender Goel, Jorn Boehnk, John Humphries, Scott Kominers, Bala Hota, Shannon Sims, Bradley Malin, Dustin French, Theresa Walunas, David Meltzer, Erin Kaleba, Roderick Jones, and William Galanter
  Journal of the American Medical Informatics Association, 2015; 22(5): 1072-1080


• Methods to Mitigate Risk of Composition Attack in Independent Publications
  Jiuyong Li, Sarowar Sattar, Muzammil Baig, Jixue Liu, Raymond Heatherly, Qiang Tang, and Bradley Malin
  A book chapter for G. Loukides and A. Gkoulalas-Divanis, eds: Medical Data Privacy Handbook, Springer Press, 2015: 179-200


• Privacy in the Genomic Era
  Muhammad Naveed, Erman Ayday, Ellen Wright Clayton, Jacques Fellay, Carl Gunter, Jean-Pierre Hubaux, Bradley Malin, and Xiaofeng Wang
  ACM Computing Surveys, 2015; 48(1): 6


• Privacy-Aware Dynamic Feature Selection
  Erman Pattuk, Murat Kantarcioglu, Huseyin Ulusoy, and Bradley Malin
  Proceedings of the 31st IEEE International Conference on Data Engineering (ICDE). 2015: 78-88.


• A Game Theoretic Framework for Analyzing Re-identification Risks
  Zhiyu Wan, Yevgeniy Vorobeychik, Weiyi Xia, Ellen Wright Clayton, Murat Kantarcioglu, Ranjit Ganta, Raymond Heatherly, and Bradley Malin
  PLoS One. 2015; 10(3): e0120592


• Inferring Clinical Worflow Efficiency via Electronic Medical Record Utilization
  You Chen, Wei Xie, Carl Gunter, David Liebovitz, Sanjay Mehotra, He Zhang, and Bradley Malin
  Proceedings of the 2015 American Medical Informatics Association Annual Symposium. 2015: forthcoming.
  


• Iterative Classification for Sanitizing Large-Scale Datasets
  Bo Li, Yevgeniy Vorobeychik, Muqun (Rachel) Li, and Bradley Malin
  Proceedings of the 15th IEEE International Conference on Data Mining. 2015: 841-846.
  


• Mining Twitter as a First Step Toward Assessing the Adequacy of Gender Identification on Intake Forms
  Amanda Hicks, William Hogan, Michael Rutherford, Bradley Malin, Mengjun Xie, Christiane Fellbaum, Zhijun Yin, Daniel Fabbri, Josh Hanna, and Jian Bian
  Proceedings of the 2015 American Medical Informatics Association Annual Symposium. 2015: forthcoming.
  


• Modeling the Complex Search Space of Data Privacy Problems
  Bradley Malin
  Proceedings of the 12th International Conference on Modeling Decisions for Artificial Intelligence (MDAI). 2015: forthcoming.
  
  
• R-U Policy Frontiers for Health Data De-identification
  Weiyi Xia, Raymond Healtherly, XiaoFeng Ding, Jiuyong Li, and Bradley Malin
  Journal of the American Medical Informatics Association. 2015; 22(5): 1029-1041


• Process-Driven Data Privacy
  Weiyi Xia, Zhiyu Wan, Yevgeniy Vorobeychik, Murat Kantarcioglu, Raymond Heatherly, and Bradley Malin
  Proceedings of the 24th ACM Conference on Information and Knowledge Management (CIKM). 2015: 1021-1030.
  
  
• A Scalable Approach to Detect Personal Health Mentions in Social Media
  Zhijun Yin, Daniel Fabbri, S. Trent Rosenbloom, and Bradley Malin
  Journal of Medical Internet Research. 2015; 17(6): e138


2014

• A Community Assessment of Privacy Preserving Techniques for Human Genomes
  Xiaoqian Jiang, Yongan Zhao, Xiaofeng Wang, Bradley Malin, Shuang Wang, Lucila Ohno-Machado, and Haixu Tang
  BMC Medical Informatics and Decision Making. 2014; 14(Suppl 1): S1.


• Composite Bloom Filters for Secure Record Linkage
  Elizabeth Ashley Durham, Murat Kantarcioglu, Yuan Xue, Csaba Toth, Mehmet Kuzu, and Bradley Malin
  IEEE Transactions on Knowledge and Data Engineering. 2014; 26(12): 2956-2968.


• Decide Now or Decide Later? Quantifying the Tradeoff between Prospective and Retrospective Access Decisions
  Wen Zhang, You Chen, Ted Cybulski, Carl A. Gunter, Daniel Fabbri, Patrick Lawlor, David Liebovitz, and Bradley Malin
  Proceedings of the 21st ACM Conference on Computer and Communications Security (CCS). 2014: 1182-1192.


• De-identification of Clinical Narratives through Writing Complexity Measures
  Rachel Li, David Carrell, John Aberdeen, Lynette Hirschman, and Bradley Malin
  International Journal of Medical Informatics. 2014; 83(10): 750-767.


• Ensuring Patient Privacy in Data Sharing for Post-Approval Research
  Ameet Sarpatwari, Aaron Kesselheim, Bradley Malin, Joshua Gagne, and Sebastian Schneeweiss
  New England Journal of Medicine. 2014; 371: 1644-1649.


• Limestone: High-throughput Candidate Phenotype Generation via Tensor Factorization
  Joyce Ho, Joydeep Ghosh, Steven Steinhubl, Walter Stewart, Josh Denny, Bradley Malin, and Jimeng Sun
  Journal of Biomedical Informatics. 2014; 52: 199-211.


• PARAMO: A PARAllel Predictive MOdeling Platform for Healthcare Analytic Research Using Electronic Health Records
  Kenny Ng, Amol Ghoting, Steven Steinhubl, Walter Stewart, Bradley Malin, and Jimeng Sun
  Journal of Biomedical Informatics. 2014; 48: 160-170


• Policy Recommendations for Addressing Privacy Challenges Associated with Cell-Based Research and Interventions
  Ubaka Ogbogu, Sarah Burningham, Adam Ollenberger, Kathry Calder, Li Du, Khaled El Emam, Robyn Hyde-Lay, Rosario Isasi, Yann Joly, Ian Kerr, Bradley Malin, Michael McDonald, Steven Penney, Gayle Piat, Denis-Claude Roy, Jeremy Sugarman, Suzanne Vercauteren, Griet Verhennemen, Lori West, and Timothy Caulfield
  BMC Medical Ethics. 2014; 15: 7.


• Predicting Changes in Hypertension Control Using Electronic Health Records from a Chronic Disease Management Program
  Jimeng Sun, Candace McNaughton, Ping Zhang, Adam Perer, Aris Gkoulalas-Divanis, Joshua Denny, Jacqueline Kirby, Thomas Lasko, Alex Saip, and Bradley Malin
  Journal of the American Medical Informatics Association. 2014; 21(2): 337-344.


• SecureMA: Protecting Participant Privacy in Genetic Association Meta-Analysis
  Wei Xie, Murat Kantarcioglu, William Bush, Dana Crawford, Josh Denny, Raymond Heatherly, and Bradley Malin
  Bioinformatics. 2014; 30(23): 3334-3341.


• Size Matters: How Population Size Influences Genotype-Phenotype Association Studies in Anonymized Data
  Raymond Heatherly, Josh Denny, Jonathan Haines, Dan Roden, and Bradley Malin
  Journal of Biomedical Informatics. 2014; 52: 243-250.


• SOEMPI: A Secure Open Enterprise Master Patient Index Software Toolkit for Private Record Linkage
  Csaba Toth, Elizabeth Ashley Durham, Murat Kantarcioglu, Yuan Xue, and Bradley Malin
  Proceedings of the American Medical Informatics Association Annual Symposium. 2014: 1105-1114.


• We Work with Them? Healthcare Worker's Interpretation of Organizational Relations Mined from Electronic Health Records
  You Chen, Nancy Lorenzi, Steve Nyemba, Jonathan Schildcrout, and Bradley Malin
  International Journal of Medical Informatics. 2014; 83(7): 495-506.


2013

• Biomedical Data Privacy: Problems, Perspectives, and Recent Advances
  Bradley Malin, Khaled El Emam, and Christine O'Keefe
  Journal of the American Medical Informatics Association. 2013; 20(1): 2-6.


• Efficient Discovery of De-identification Policies Through a Risk-Utility Frontier
  Weiyi Xia, Raymond Heatherly, Xiaofeng Ding, Jiuyong Li, and Bradley Malin
  Proceedings of the 3rd ACM Conference on Data and Applications Privacy and Security (CODASPY). 2013: 59-70.


• Efficient Privacy-Aware Record Integration
  Mehmet Kuzu, Murat Kantarcioglu, Ali Inan, Elisa Bertino, Elizabeth Ashley Durham, and Bradley Malin
  Proceedings of the 16th International Conference on Extending Database Technology (EDBT). 2013: 167-178.


• Enabling Genomic-Phenomic Association Discovery Without Sacrificing Anonymity
  Raymond Heatherly, Grigorios Loukides, Joshua Denny, Jonathan Haines, Dan Roden, and Bradley Malin
  PLoS One. 2013; 8(2): e53875.


• Ethical, Legal, and Social Implications of Incorporating Genetic Information into Electronic Health Records
  Ribhi Hazin, Kyle Brothers, Bradley Malin, Barbara Koenig, Saskia Sanderson, Mark Rothstein, Marc Williams, Ellen Wright Clayton, and Iftikhar Kullo
  Genetics in Medicine. 2013; 15(10): 810-816.


• Evolving Role Definitions Through Permission Invocation Patterns
  Wen Zhang, You Chen, Carl Gunter, David Liebovitz, and Bradley Malin
  Proceedings of the 18th ACM Symposium on Access Control Models and Technologies (SACMAT). 2013: 37-48.


• Hiding in Plain Sight: Use of Realistic Surrogates to Reduce Exposure of Protected Health Information in Clinical Text
  David Carrell, Bradley Malin, John Aberdeen, Samuel Bayer, Cheryl Clark, Ben Wellner, and Lynette Hirschman
  Journal of the American Medical Informatics Association. 2013; 20(2): 342-348.


• Location Bias of Identifiers in Clinical Narratives
  David Hanauer, Kai Zheng, Bradley Malin, and Qiaozhu Mei
  Proceedings of the American Medical Informatics Association Annual Symposium. 2013: 560-569.


• Mining Deviations from Patient Care Pathways via Electronic Medical Record System Audits
  He Zhang, Sanjay Mehotra, David Liebovitz, Carl Gunter, and Bradley Malin
  ACM Transactions on Management Information Systems. 2013; 4(4): 17.


• Modeling and Detecting Anomalous Topic Access
  Siddharth Gupta, Casey Hanson, Carl Gunter, Mario Frank, David Liebovitz, and Bradley Malin
  Proceedings of the 11th IEEE International Conference on Intelligence and Security Informatics (ISI). 2013: 100-105.


• A Practical Approach to Achieve Private Medical Record Linkage in Light of Public Resources
  Mehmet Kuzu, Murat Kantarcioglu, Elizabeth Ashley Durham, Csaba Toth, and Bradley Malin
  Journal of the American Medical Informatics Association. 2013; 20(2): 285-292.


• A Probabilistic Approach to Mitigate Composition Attacks on Privacy in Non-coordinated Environments
  A.H.M. Sarowar Sattar, Jiuyong Li, Jixue Liu, Raymond Heatherly, and Bradley Malin
  Knowledge-Based Systems. Forthcoming.


• Reducing Patient Re-identification Risk for Laboratory Results Within Research Datasets
  Ravi Atreya, Josh Smith, Allison McCoy, Bradley Malin, and Randolph Miller
  Journal of the American Medical Informatics Association. 2013; 20(1): 95-101.


• Requirements and Design for an Extensible Toolkit for Analyzing EMR Audit Logs
  Eric Duffy, Steve Nyemba, Carl Gunter, David Liebovitz, and Bradley Malin
  Proceedings of the 1st USENIX Workshop on Health Information Technologies. 2013: 6.


• Scalable and Robust Key Group Size Estimation for Reducer Load Balancing in MapReduce
  Wei Yan, Yuan Xue, and Bradley Malin
  Proceedings of the 1st IEEE International Conference on Big Data. 2013: 156-162.


• Scalable Load Balancing for MapReduce-based Record Linkage
  Wei Yan, Yuan Xue, and Bradley Malin
  Proceedings of the 32nd IEEE International Performance Computing and Communications Conference. 2013: 1-10.


• State of the Art in Clinical Informatics: Evidence and Examples
  Allison McCoy, Adam Wright, Gunther Eysenbach, Bradley Malin, Emily Patterson, Hua Xu, and Dean Sittig
  Yearbook of Medical Informatics. 2013; 8(1): 13-19.


• Studying Patients Who Opt Out of Large-Scale Biorepository Research
  S. Trent Rosenbloom, Jennifer Madison, Kyle Brothers, Erica Bowton, Ellen Wright Clayton, Bradley Malin, Dan Roden, and Jill Pulley
  Journal of the American Medical Informatics Association. 2013; 20(e2): e221-e225.


2012

• Anonymization of Longitudinal Electronic Medical Records
  Acar Tamersoy, Grigorios Loukides, Mehmet Nergiz, Yucel Saygin, and Bradley Malin
  IEEE Transactions on Information Technology in Biomedicine. 2012; 16: 413-423.


• Auditing Medical Record Accesses via Healthcare Interaction Networks
  You Chen, Steve Nyemba, and Bradley Malin
  Proceedings of the 2012 American Medical Informatics Association Annual Symposium. 2012: 93-102.


• Secure Management of Biomedical Data with Cryptographic Hardware
  Mustafa Canim, Murat Kantarcioglu, and Bradley Malin
  IEEE Transactions on Information Technology in Biomedicine. 2012; 16: 166-175.


• Detecting Anomalous User Behaviors in Workflow-Driven Web Applications
  Xiaowei Li, Yuan Xue, and Bradley Malin
  Proceedings of the 31st International Symposium on Reliable Distributed Systems (SRDS). 2012: 1-10.


• Detecting Anomalous Insiders in Collaborative Information Systems
  You Chen, Steve Nyemba, and Bradley Malin
  IEEE Transactions on Dependable and Secure Computing. 2012; 9(3): 332-344.
  Award: Named by ACM Computing Reviews as one of the best papers of 2012


• Quantifying the Correctness, Computational Complexity, and Security of Privacy-Preserving String Comparators for Record Linkage
  Elizabeth Ashley Durham, Yuan Xue, Murat Kantarcioglu, and Bradley Malin
  Information Fusion. 2012; 13: 245-259.


• Specializing Network Analysis to Detect Anomalous Insider Actions
  You Chen, Steve Nyemba, Wen Zhang, and Bradley Malin
  Security Informatics. 2012; 1: 5.


2011

• COAT: Constraint-based Anonymization of Transactions
  Grigorios Loukides, Aris Gkoulalas-Divanis, and Bradley Malin
  Knowledge and Information Systems. 2011; 28: 251-282.


• A Constraint Satisfaction Cryptanalysis of Bloom Filters in Private Record Linkage
  Mehmet Kuzu, Murat Kantarcioglu, Elizabeth Ashley Durham, and Bradley Malin
  Lecture Notes in Computer Science: Proceedings of the 11th Privacy Enhancing Technologies Symposium (PETS), vol. 6794, 2011: 226-245.


• Detection of Anomalous Insiders in Collaborative Environments via Relational Analysis of Access Logs
  You Chen and Bradley Malin
  Proceedings of the ACM Conference on Data and Application Security and Privacy. 2011: 63-74.


• An Entropy Approach to Disclosure Risk Assessment: Lessons from Real Applications and Simulated Domains
  Edoardo Airoldi, Xue Bai, and Bradley Malin
  Decision Support Systems. 2011; 51: 10-20.


• Experience-Based Access Management: A Lifecycle Framework to Evolve Identity and Access Management Systems
  Carl Gunter, David Liebovitz, and Bradley Malin
  IEEE Security and Privacy Magazine. 2011; 9: 48-55.


• Identifiability in Biobanks: Models, Measures, and Mitigation Strategies
  Bradley Malin, Grigorios Loukides, Kathleen Benitez, Ellen Wright Clayton
  Human Genetics. 2011; 130(3): 383-392.


• Learning Relational Policies from Electronic Health Record Access Logs
  Bradley Malin, Steve Nyemba, and John Paulett
  Journal of Biomedical Informatics. 2011; 44: 333-342.


• Leveraging Social Networks to Detect Anomalous Insider Actions in Collaborative Environments
  You Chen, Steve Nyemba, Wen Zhang, and Bradley Malin
  Proceedings of the IEEE International Conference on Intelligence and Security Informatics. 2011: 119-124.


• Never Too Old for Anonymity: A Statistical Standard for Demographic Data Sharing via the HIPAA Privacy Rule
  Bradley Malin, Kathleen Benitez, and Daniel Masys
  Journal of the American Medical Informatics Association. 2011; 18(1): 3-10.


• Role Prediction using Electronic Medical Record System Audits
  Wen Zhang, Carl Gunter, David Liebovitz, Jian Tian, and Bradley Malin
  Proceedings of the 2011 American Medical Informatics Association Annual Symposium. 2011: 858-867.


• A Secure Protocol for Protecting the Identity of Providers When Disclosing Data for Disease Surveillance
  Khaled El Emam, Jun Hu, Jay Mercer, Liam Peyton, Murat Kantarcioglu, Bradley Malin, David Buckeridge, Saeed Samet, and Craig Earle
  Journal of the American Medical Informatics Association. 2011; 18(3): 212-217.


• A Survey of Challenges and Solutions for Privacy in Clinical Genomics Data Mining
  Bradley Malin, Chris Cassa, and Murat Kantarcioglu
  A book chapter for: F. Bonchi and E. Ferrari, eds: Privacy-Aware Knowledge Discovery: Novel Applications and New Techniques, Chapman & Hall / CRC Press. 2011.


• A Systematic Review of Re-identification Attacks on Health Data
  Khaled El Emam, Elizabeth Jonker, Luk Arbuckle, and Bradley Malin
  PLoS One. 2011; 6: e28071.


• Towards Understanding the Usage Pattern of Web-based Electronic Medical Record Systems
  Xiaowei Li, Yuan Xue, and Bradley Malin
  Proceedings of the IEEE International Workshop on Interdisciplinary Research on E-Health Services and Systems. 2011.


2010

• Anonymization of Administrative Billing Codes with Repeated Diagnoses through Censoring
  Acar Tamersoy, Grigorios Loukides, Josh Denny, and Bradley Malin
  Proceedings of the 2010 American Medical Informatics Association Annual Symposium. 2010: 782-786.


• Anonymization of Electronic Medical Records for Validating Genome Wide Association Studies
  Grigorios Loukides, Aris Gkoulalas-Divanis, and Bradley Malin
  Proceedings of the National Academy of Sciences. 2010; 107(17): 7898-7903.


• Beyond Safe Harbor: Automatic Discovery of Health Information De-identification Policy Alternatives
  Kathleen Benitez, Grigorios Loukides, and Bradley Malin
  Proceedings of the ACM International Health Informatics Symposium. 2010: 163-172.


• The Disclosure of Diagnosis Codes can Breach Research Participants' Privacy
  Grigorios Loukides, Josh Denny, and Bradley Malin
  Journal of the American Medical Informatics Association. 2010; 17(3): 322-327.


• Effects of Personal Identifier Resynthesis on Clinical Text De-identification
  Reyyan Yeniterzi, John Aberdeen, Sam Bayer, Ben Wellner, Lynette Hirschman, and Bradley Malin
  Journal of the American Medical Informatics Association. 2010; 17: 159-168.
  


• Evaluating Re-identification Risks with Respect to the HIPAA Privacy Rule
  Kathleen Benitez and Bradley Malin
  Journal of the American Medical Informatics Association. 2010; 17: 167-177.
  


• An Integrative, Anonymity-Preserving Framework for Disseminating Clinical and Genomic Data
  Grigorios Loukides, Aris Gkoulalas-Divanis, and Bradley Malin
  A book chapter for: C. Plant and C. Bohm, eds. Database Technology for Life Sciences and Medicine. World Scientific. 2010.


• The MITRE Identification Scrubber Toolkit: Design, Training, and Assessment
  John Aberdeen, Sam Bayer, Reyyan Yeniterzi, Ben Wellner, Cheryl Clark, David Hanauer, Bradley Malin, and Lynette Hirschman
  International Journal of Medical Informatics. 2010; 79(12): 849-859.


• Private Medical Record Linkage with Approximate Matching
  Elizabeth Ashley Durham, Murat Kantarciolgu, Yuan Xue, and Bradley Malin
  Proceedings of the 2010 American Medical Informatics Association Annual Symposium. 2010: 182-186.


• Privacy-Preserving Publication of Diagnosis Codes for Effective Biomedical Analysis
  Grigorios Loukides, Aris Gkoulalas-Divanis, and Bradley Malin
  Proceedings of the 10th IEEE International Conference on Information Technology and Applications in Biomedicine. 2010: forthcoming.


• Secure Construction of K-unlinkable Patient Records from Distributed Providers.
  Bradley Malin
  Artificial Intelligence in Medicine. 2010; 48: 29-41.


• Technical and Policy Approaches to Balancing Patient Privacy and Data Sharing in Clinical and Translational Research.
  Bradley Malin, David Karp, and Richard Scheuermann
  Journal of Investigative Medicine. 2010; 58(1): 11-18.

2009

• Do Clinical Profiles Constitute Privacy Risks for Research Participants?
  Grigorios Loukides, Josh Denny, and Bradley Malin
  Proceedings of the 2009 American Medical Informatics Association Annual Symposium (AMIA).
  Winner of the Distinguished Paper Award.
  (This paper was published as an extended abstract. It was subsequently published as "The Disclosure of Diagnosis Codes can Breach Research Participants' Privacy".)


• Formal Anonymity Models for Efficient Privacy Preserving Joins.
  Murat Kantarcioglu, Ali Inan, Wei Jiang, and Bradley Malin
  Data and Knowledge Engineering. 2009; 68(11): 1206-1223.

2008

• A Cryptographic Approach to Securely Share and Query Genomic Sequences.
  Murat Kantarcioglu, Wei Jiang, Ying Liu, and Bradley Malin
  IEEE Transactions on Information Technology in Biomedicine. 2008;12(5): 606-617.


• Ethical and Practical Issues Associated with Aggregating Databases.
  David Karp, Sheryl Carlin, Robert Cook-Deegan, Daniel Ford, Gail Geller, David Glass, Henry Greely, Joel Guthridge, Jeffrey Kahn, Richard Kaslow, Cheryl Kraft, Kathleen MacQueen, Bradley Malin, Richard Scheuermann, and Jeremy Sugarman
  PLoS Medicine. 2008; 5(9): e190.


• Integration of Clinical Workflows with Privacy Policies on a Common Semantic Platform.
  Jan Werner, Bradley Malin, Yonghwan Lee, Akos Ledeczi, and Janos Sztipanovits
  Proceedings of the 2nd ACM/IEEE International Workshop on Model-Based Trustworthy Health Information Systems. Toulouse, France. 2008.


• K-unlinkability: a Privacy Protection Model for Distributed Data.
  Bradley Malin
  Data and Knowledge Engineering. 2008; 64(1): 294-311.


• Model-Based Design of Clinical Information Systems.
  Janos Mathe, Jan Werner, Yonghwan Lee, Bradley Malin, and Akos Ledeczi
  Methods of Information in Medicine. 2008; 47: 399-408.


• A Privacy-Preserving Framework for Integrating Person-Specific Databases.
  Murat Kantarcioglu, Wei Jiang, and Bradley Malin
  Springer Lecture Notes in Computer Science: Proceedings of the 2008 International Conference on Privacy in Statistical Databases. Istanbul, Turkey. 2008; 5262: 298-314.

Related Links

• Department of Biomedical Informatics, Vanderbilt University
• Department of Electrical Engineering and Computer Science, Vanderbilt University
• Department of Biostatistics, Vanderbilt University
• Health Data Science Center, Vanderbilt University
• Genetic Privacy and Identity in Community Settings Center, Vanderbilt University
• Electronic Medical Records and Genomics Network, NIH sponsored
• The Mid-South Clinical Data Research Network, PCORI sponsored

Positions Available

Post-doctoral researchers, Ph.D. students, & programmers. Work on biomedical data privacy, data mining, & systems implementation.

Media On Our Research

On our winning solution to the iDASH Genome Privacy Competition (2016)




Genome Magazine article (2014)




GenomeWeb article (2013)




Nature News Science News Technology Review reports on our electronic medical record anonymization algorithms (2010)


Award!

Detecting Anomalous Insiders in Collaborative Information Systems was named a top article of 2012 by ACM Computing Reviews

Recent Publications

A Game Theoretic Framework for Analyzing Re-identification Risks PLoS One




Optimizing Annotation Resources for Natural Language De-identification via a Game Theoretic Framework Journal of Biomedical Informatics




Preserving Temporal Relations in Clinical Data While Maintaining Privacy Journal of the American Medical Informatics Association




Optimizing Secure Classification Performance with Privacy-Aware Feature Selection 32nd IEEE International Conference on Data Engineering